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Surface Enhanced Resonance Raman Scattering (SERRS)—A First Example of its Use in Multiplex Genotyping
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2001
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Genetic TestingEngineeringGeneticsSurface-enhanced Raman ScatteringMolecular BiologyPathologyMolecular GeneticsDisease Gene IdentificationGenomicsGenetic AnalysisModern Dna AssaysMendelian DisorderMolecular DiagnosticsBiophysicsNanophotonicsCystic Fibrosis GeneSelective Serrs TechniqueMolecular Diagnostic TechniquesSpectroscopyApplied PhysicsMedicineSpectroscopic MethodFirst ExampleMultiplex Genotyping
Accurate multiplex genotyping of the mutational status of the cystic fibrosis gene with the sensitive and selective SERRS technique is reported. This new assay does not require separation of the various alleles and shows that SERRS is a realistic alternative detection technique for use in modern DNA assays.