QUANTITATIVE CONTRIBUTION OF CYP2D6 AND CYP3A TO OXYCODONE METABOLISM IN HUMAN LIVER AND INTESTINAL MICROSOMES

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

R. Scott Obach · Drug Metabolism and Disposition · 1999 · 1.2K citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Efficacy of oxycodone in neuronathic pain

Carolyn Watson, Najib Babul · Neurology · 1998 · 649 citations

Medicine, Neurology, Pharmacotherapy +17

Co-Regulation of CYP3A4 and CYP3A5 and Contribution to Hepatic and Intestinal Midazolam Metabolism

Yvonne S. Lin, Amy L.S. Dowling, Sean Quigley et al. · Molecular Pharmacology · 2002 · 444 citations

Medicine, Molecular Biology, Pharmacology +17

The pharmacokinetics and metabolism of oxycodone after intramuscular and oral administration to healthy subjects.

Reino Pöyhiä, Toni T. Seppälä, Eija Kalso · British Journal of Clinical Pharmacology · 1992 · 286 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +16

High-performance liquid chromatographic assays for bufuralol 1′-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver

Thomas Kronbach, Daniel Mathys, Josef Gut et al. · Analytical Biochemistry · 1987 · 262 citations

Medicine, Biochemistry, Pharmacology +17