Automated production of monoclonal antibodies in a cytostat

Continuous cultures of fused cells secreting antibody of predefined specificity

Georges Köhler, César Milstein · Nature · 1975 · 17.2K citations

Pharmacy, Cell Biology, Immunology +11

DISQUISITIONS ON ORIGINAL ANTIGENIC SIN

S. Groth, Robert G. Webster · The Journal of Experimental Medicine · 1966 · 576 citations · Full text

Life Sciences, Immunology, Adaptive Immunity +16

Complete replacement of serum by albumin, transferrin, and soybean lipid in cultures of lipopolysaccharide-reactive B lymphocytes.

Norman N. Iscove, Fritz Melchers · The Journal of Experimental Medicine · 1978 · 535 citations · Full text

Life Sciences, Biochemistry, Immunology +17

Partial replacement of serum by selenite, transferrin, albumin and lecithin in haemopoitec cell cultures

L.J. Guilbert, Norman N. Iscove · Nature · 1976 · 319 citations

Life Sciences, Biochemistry, Cell Biology +8

Complete replacement of serum in primary cultures of erythropoietin-dependent red cell precursors (CFU-E) by albumin, transferrin, iron, unsaturated fatty acid, lecithin and cholesterol

Norman N. Iscove, L.J. Guilbert, Christine Weyman · Experimental Cell Research · 1980 · 249 citations

Life Sciences, Biochemistry, Physiology +8