Bone targeted drugs 2. synthesis of estrogens with hydroxyapatite affinity

A Simple and Sensitive Microtiter Plate Estrogen Bioassay Based on Stimulation of Alkaline Phosphatase in Ishikawa Cells: Estrogenic Action of Δ⁵Adrenal Steroids*

Bruce A. Littlefield, Erlio Gurpide, Leszek Markiewicz et al. · Endocrinology · 1990 · 181 citations

Life Sciences, Biochemistry, Endocrinology +14

3-[4-(1,2-Diphenylbut-1-enyl)phenyl]acrylic Acid: A Non-Steroidal Estrogen with Functional Selectivity for Bone over Uterus in Rats

Timothy M. Willson, Brad R. Henke, Tanya M. Momtahen et al. · Journal of Medicinal Chemistry · 1994 · 147 citations

Medicine, Endocrinology, Pharmacology +14

Nonsteroidal estrogens: synthesis and estrogen receptor binding affinity of derivatives of (3R*,4S*)-3,4-bis(4-hydroxyphenyl)hexane (hexestrol) and (2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentane (norhexestrol) functionalized on the side chain

Scott W. Landvatter, John A. Katzenellenbogen · Journal of Medicinal Chemistry · 1982 · 36 citations

Life Sciences, Medicinal Chemistry, Pharmacology +9

Synthesis of β-estradiol-3-benzoate-17-(succinyl-12A-tetracycline): A potential bone-seeking estrogen

Mark Orme, Virender M. Labroo · Bioorganic & Medicinal Chemistry Letters · 1994 · 30 citations

Medicine, Endocrinology, Bone Metabolism +8

Acidic epinephrine analogs derived from 1H,3H-2,1,3-benzothiadiazole 2,2-dioxide and from trifluoromethanesulfonanilide. New synthesis of 1H,3H-2,1,3-benzothiadiazole 2,2-dioxide

R. M. Acheson, M. G. BITE, J. E. G. KEMP · Journal of Medicinal Chemistry · 1981 · 17 citations

Natural Sciences, Chemistry, Medicinal Chemistry +9