Bruce A. Littlefield

The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth

Mary Ann Jordan, Kathryn Kamath, Tapas Manna et al. · Molecular Cancer Therapeutics · 2005 · 494 citations

Medicine, Oncology, Pharmacology +17

In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B.

Murray J. Towle, Kathleen A. Salvato, John Budrow et al. · PubMed · 2001 · 491 citations

Medicine, Medicinal Chemistry, Oncology +15

Eribulin Binds at Microtubule Ends to a Single Site on Tubulin To Suppress Dynamic Instability

Jennifer Smith, Leslie Wilson, Olga Azarenko et al. · Biochemistry · 2009 · 325 citations · Full text

Medicine, Oncology, Pharmacology +15

Induction of Morphological and Biochemical Apoptosis following Prolonged Mitotic Blockage by Halichondrin B Macrocyclic Ketone Analog E7389

Galina Kuznetsov, Murray J. Towle, Hongsheng Cheng et al. · Cancer Research · 2004 · 267 citations

Medicine, Oncology, Pharmacology +17

Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase

Tatiana Okouneva, Olga Azarenko, Leslie Wilson et al. · Molecular Cancer Therapeutics · 2008 · 207 citations · Full text

Life Sciences, Cell Biology, Oncology +17