Potential bias and mitigations when using stable isotope labeled parent drug as internal standard for LC–MS/MS quantitation of metabolites

Matrix Effect in Quantitative LC/MS/MS Analyses of Biological Fluids:  A Method for Determination of Finasteride in Human Plasma at Picogram Per Milliliter Concentrations

B.K. Matuszewski, M.L. Constanzer, C.M. Chavez-Eng · Analytical Chemistry · 1998 · 879 citations

Pharmacy, Pharmaceutical Analysis, Pharmacology +17

A Predictive Model for Matrix and Analyte Effects in Electrospray Ionization of Singly-Charged Ionic Analytes

Christie G. Enke · Analytical Chemistry · 1997 · 417 citations

Natural Sciences, Chemical Engineering, Chemistry +15

Liquid chromatography–mass spectrometry/mass spectrometry method development for drug metabolism studies: Examining lipid matrix ionization effects in plasma

Julian Little, Michael F. Wempe, Charles Buchanan · Journal of Chromatography B · 2006 · 253 citations

Pharmacy, Pharmacokinetics, Pharmacology +14

Ionization enhancement in atmospheric pressure chemical ionization and suppression in electrospray ionization between target drugs and stable‐isotope‐labeled internal standards in quantitative liquid chromatography/tandem mass spectrometry

Huakun Liang, R. L. Foltz, Patrick Bennett · Rapid Communications in Mass Spectrometry · 2003 · 250 citations

Pharmacy, Chemistry, Pharmaceutical Analysis +17

Matrix effects during analysis of plasma samples by electrospray and atmospheric pressure chemical ionization mass spectrometry: practical approaches to their elimination

Joachim Schuhmacher, Dieter Zimmer, Frank Tesche et al. · Rapid Communications in Mass Spectrometry · 2003 · 153 citations

Pharmacy, Pharmacokinetics, Pharmacology +15