Concepedia

Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells

Sha Mi, Robert H. Miller, Wei Tang, Xinhua Lee, Bing Hu, Wutain Wu, Yiping Zhang, Christopher B. Shields, Yongjie Zhang, Steven D. Miklasz,

Annals of Neurology · 2009 · 299 citations · 23 references

DOIFull text

Open access

Abstract

Our studies demonstrate that LINGO-1 antagonism promotes OPC differentiation and remyelination, and suggest LINGO-1 functions as an inhibitor of OPC differentiation to retard central nervous system remyelination.

References

23

Premyelinating Oligodendrocytes in Chronic Lesions of Multiple Sclerosis

Ansi Chang, Wallace W. Tourtellotte, Richard A. Rudick et al. · New England Journal of Medicine · 2002 · 976 citations · Full text

Myelin Impairs CNS Remyelination by Inhibiting Oligodendrocyte Precursor Cell Differentiation

Mark Kotter, Wenwu Li, Chao Zhao et al. · Journal of Neuroscience · 2006 · 766 citations · Full text

, , +12

LINGO-1 negatively regulates myelination by oligodendrocytes

Sha Mi, Robert H. Miller, Xinhua Lee et al. · Nature Neuroscience · 2005 · 611 citations

, , +7

Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation

Stephen A. Back, Thérèse M.F. Tuohy, Hanqin Chen et al. · Nature Medicine · 2005 · 596 citations

, , +8

LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis

Sha Mi, Bing Hu, Kyungmin Hahm et al. · Nature Medicine · 2007 · 484 citations

, , +10