Canadian Journal of Chemistry · 1987 · 33 citations · 3 references
PharmacyMedicinal ChemistryPharmacologyDrug DiscoveryOrganic ChemistrySynthetic Medicinal ChemistryAntitumor AntibioticsMacrocycle SynthesisNatural Product Drug DiscoveryOrganic SynthesisAntibiotic DiscoveryAntitumor Antibiotic BiosynthesisNatural Product Total SynthesisTotal Synthesis-derived Analogues
The synthesis of 1-hydroxy-10,12-dimethoxy-8-vinyl-6H-benzo[d]naphtho[1, 2b]pyran-6-one 7, starting from vanillin and 1,5-dihydroxynaphthalene is described. This compound is the aglycone of the antitumor antibiotic ravidomycin and is identical with the recently reported antimicrobial agent, defucogilvocarcin V.
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