Bile acids increase the activity of the epithelial Na+ channel

Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits

Cecilia M. Canessa, Laurent Schild, Gary Buell et al. · Nature · 1994 · 2K citations

Natural Sciences, Biochemistry, Biophysics +13

Liddle's syndrome: Heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel

Richard A. Shimkets, David G. Warnock, Christopher M. Bositis et al. · Cell · 1994 · 1.3K citations

Life Sciences, Genetics, Molecular Genetics +15

Structure of acid-sensing ion channel 1 at 1.9 Å resolution and low pH

J. Jasti, Hiroyasu Furukawa, Eric B. Gonzales et al. · Nature · 2007 · 1.1K citations

Natural Sciences, Biochemistry, Biophysics +15

Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1

Su'e Chang, Stefan Gründer, Aaron Hanukoglu et al. · Nature Genetics · 1996 · 814 citations

Medicine, Molecular Genetics, Physiology +15

Hypertension caused by a truncated epithelial sodium channel γ subunit: genetic heterogeneity of Liddle syndrome

Joni H. Hansson, Carol Nelson‐Williams, Hiroshi Suzuki et al. · Nature Genetics · 1995 · 754 citations

Life Sciences, Genetics, Molecular Genetics +13