Prognostic Significance of Microsatellite Instability and Ki-<i>ras</i> Mutation Type in Stage II Colorectal Cancer

Abstract

MSI+ and Ki-RAS mutation type are not useful markers for the identification of high-risk stage II CRC patients. Further prospective and/or cohort studies are required to determine whether these molecular changes have predictive value for survival benefit from 5-fluorouracil-based adjuvant chemotherapy.