Prospective Study of the Effects of Antiretroviral Therapy on Kaposi Sarcoma–Associated Herpesvirus Infection in Patients With and Without Kaposi Sarcoma

Abstract

To our knowledge, we demonstrate for the first time that both protease inhibitor-based and nonnucleoside reverse transcriptase inhibitor-based antiretroviral treatment combinations may lead to an undetectable KSHV load and confirm that an undetectable KSHV load is associated with KS regression. There was no clear association between CD4 cell count response and KS response to HAART, but there was a significant relationship between HIV load response to HAART and clinical improvement of KS.