Concepedia

Cyanovirin-N binding to Manα1–2Man functionalized dendrimers

Shane Mangold, Joel R. Morgan, Gregory C. Strohmeyer, Angela M. Gronenborn, Mary J. Cloninger

Organic & Biomolecular Chemistry · 2005 · 20 citations · 42 references

DOI

Concepts

Abstract

Manα1–2Man functionalized G(3) and G(4)–PAMAM dendrimers have been synthesized and characterized by MALDI-TOF MS and NMR spectroscopy. Precipitation assays to assess the binding of the dimannose-functionalized dendrimers to Cyanovirin-N, a HIV-inactivating protein that blocks virus-to-cell fusion through high mannose mediated interactions, are presented.

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