Publication | Closed Access
Total Synthesis of Methoxyhygromycin and Its 5-Epimer
18
Citations
2
References
1990
Year
Medicinal ChemistryBiochemistryAntibioticsAbstract MethoxyhygromycinAntibacterial ActivityMedicineNatural SciencesUnique StructureTotal SynthesisAntibacterial AgentAntimicrobial ChemotherapyStereoselective SynthesisAntimicrobial CompoundPharmacologyPharmaceutical ChemistrySynthetic ChemistryDrug DiscoveryNatural Product Synthesis
Abstract Methoxyhygromycin, an antibiotic having a unique structure among the aminocyclitol antibiotics, and its 5-epimer are first synthesized. This synthesis fully confirmed the proposed structure of the antibiotic and revealed that neo-configuration of cyclitol moiety is important for the appearance of antibacterial activity.
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