Characterization of a Stable, Metronidazole-Resistant Clostridium difficile Clinical Isolate

Abstract

This is the first characterization of stable, metronidazole resistance in a C. difficile isolate. The study provides an in-depth genomic and phenotypic analysis of this strain and provides a foundation for future studies to elucidate mechanisms conferring metronidazole resistance in C. difficile that have not been previously described.