In the rat forced swimming test, chronic but not subacute administration of dual 5-HT/NA antidepressant treatments may produce greater effects than selective drugs

Depression: a new animal model sensitive to antidepressant treatments

Roger D. Porsolt, Manuel Pichon, M Jalfre · Nature · 1977 · 4.4K citations

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Behavioural despair in rats: A new model sensitive to antidepressant treatments

Roger D. Porsolt, Guy Anton, N. Blavet et al. · European Journal of Pharmacology · 1978 · 3.1K citations

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Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants

Michael J. Detke, Michael R. Rickels, Irwin Lucki · Psychopharmacology · 1995 · 1.4K citations

Medicine, Neuroscience, Pharmacology +14

Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidine

T.H. Svensson, B.S. Bunney, George K. Aghajanian · Brain Research · 1975 · 1K citations

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Immobility induced by forced swimming in rats: Effects of agents which modify central catecholamine and serotonin activity

Roger D. Porsolt, Anne Bertin, N. Blavet et al. · European Journal of Pharmacology · 1979 · 577 citations

Medicine, Neuroscience, Pharmacology +14