Immobility induced by forced swimming in rats: Effects of agents which modify central catecholamine and serotonin activity

Depression: a new animal model sensitive to antidepressant treatments

Roger D. Porsolt, Manuel Pichon, M Jalfre · Nature · 1977 · 4.4K citations

Medicine, Neuroscience, Psychiatry +12

Behavioral despair in mice: a primary screening test for antidepressants.

Porsolt Rd, Aurélie Bertin, M Jalfre · PubMed · 1977 · 3.3K citations

Medicine, Pharmacology, Psychiatry +17

Behavioural despair in rats: A new model sensitive to antidepressant treatments

Roger D. Porsolt, Guy Anton, N. Blavet et al. · European Journal of Pharmacology · 1978 · 3.1K citations

Medicine, Behavioral Sciences, Neurobiology +13

p-CHLOROPHENYLALANINE: A SPECIFIC DEPLETOR OF BRAIN SEROTONIN

B. Kenneth Koe, Albert Weissman · Journal of Pharmacology and Experimental Therapeutics · 1966 · 1.8K citations

Medicine, Neuroscience, Pharmacology +15

Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-methyl-α-ethyl-meta-tyramine

Arvid Carlsson, H. Corrodi, Kjell Fuxé et al. · European Journal of Pharmacology · 1969 · 648 citations

Medicine, Neuroscience, Pharmacology +14