Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

Jérôme Galon, Anne Costes, Fátima Sánchez‐Cabo, +13

Science

Tumor ImmunologyCancer ImmunosurveillanceAdaptive Immune ResponseMedicineImmunology +10

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

Arash Grakoui, Shannon K. Bromley, Cenk Sumen, +4

Science

Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes

Richard A. Morgan, Mark E. Dudley, John R. Wunderlich, +13

Science

Lymphoid NeoplasiaCell TherapyCancer ImmunosurveillanceMedicineCancer Regression +11

Adoptive Cell Transfer Therapy Following Non-Myeloablative but Lymphodepleting Chemotherapy for the Treatment of Patients With Refractory Metastatic Melanoma

Mark E. Dudley, John R. Wunderlich, James Chih‐Hsin Yang, +18

Journal of Clinical Oncology

Tumor Regression in Cancer Patients by Very Low Doses of a T Cell–Engaging Antibody

Ralf C. Bargou, Eugen Leo, Gerhard Zugmaier, +16

Science

ImmunologyImmunoeditingCancer PatientsImmune Cell TherapyT Cells +16

Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance

Xuefang Cao, Sheng F. Cai, Todd A. Fehniger, +4

Immunity

Cancer ImmunosurveillanceCell SignalingT-regulatory CellImmunologyGranzyme B +9

The Immunological Synapse of CTL Contains a Secretory Domain and Membrane Bridges

Jane C. Stinchcombe, Giovanna Bossi, Sarah Booth, +1

Immunity

Protein SecretionSignal TransductionMedicineSynaptic TransmissionCell Trafficking +11

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B

Alison J. Darmon, Donald W. Nicholson, R. Chris Bleackley

Nature

Apoptotic Protease Cpp32Signal TransductionProtein FunctionBiochemistryMedicine +11

Hybrid antibodies can target sites for attack by T cells

Uwe D. Staerz, Osami Kanagawa, Michael J. Bevan

Nature

Autoimmune DiseaseAdaptive Immune SystemT-regulatory CellImmunologyHybrid Antibodies +8

Induction of regular cytolytic T cell synapses by bispecific single-chain antibody constructs on MHC class I-negative tumor cells

Sonja Offner, Robert Hofmeister, Andrea Romaniuk, +2

Molecular Immunology

ImmunologyTumor ImmunityImmunodominanceAntigen ProcessingAutoimmunity +5