Increased Dihydrofolate Reductase Activity as a Possible Basis of Drug Resistance in Leukæmia

ENZYMATIC REDUCTION OF FOLIC ACID AND DIHYDROFOLIC ACID TO TETRAHYDROFOLIC ACID

Sidney Futterman · Journal of Biological Chemistry · 1957 · 414 citations · Full text

Life Sciences, Biochemistry, Biocatalysis +7

Enzymatic Reduction of Dihydrofolic Acid

Mary Osborn, F.M. Huennekens · Journal of Biological Chemistry · 1958 · 250 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +6

Inhibition of Dihydrofolic Reductase by Aminopterin and Amethopterin.

Mary Osborn, M. Freeman, F.M. Huennekens · Experimental Biology and Medicine · 1958 · 220 citations

Life Sciences, Biochemistry, Pharmacology +6

On the Mechanism of Action of Aminopterin.

Charles A. Nichol, Arnold D. Welch · Experimental Biology and Medicine · 1950 · 141 citations

Life Sciences, Biochemistry, Pharmacology +7

Possible Enzymic Mechanism for the Development of Resistance against Fluorouracil in Ascites Tumours

Peter Reichard, Ola Sköld, George Klein · Nature · 1959 · 91 citations

Medicine, Oncology, Pharmacology +14