Possible Enzymic Mechanism for the Development of Resistance against Fluorouracil in Ascites Tumours

Fluorinated Pyrimidines, A New Class of Tumour-Inhibitory Compounds

Charles Heidelberger, P Danneberg, Dorothy Mooren et al. · Nature · 1957 · 1.6K citations

Medicine, Medicinal Chemistry, Oncology +11

THE MODE OF ACTION OF 5-FLUOROURACIL AND ITS DERIVATIVES

Seymour S. Cohen, Joel G. Flaks, Hazel D. Barner et al. · Proceedings of the National Academy of Sciences · 1958 · 639 citations · Full text

Life Sciences, Pharmacology, Psychology +17

Studies on fluorinated pyrimidines. II. Effects on transplanted tumors.

Charles Heidelberger, Lois Griesbach, Betty Jo Montag et al. · PubMed · 1958 · 431 citations

Medicine, Oncology, Pharmacology +13

Studies on fluorinated pyrimidines. IV. Effects on nucleic acid metabolism in vivo.

Charles Heidelberger · PubMed · 1958 · 263 citations

Life Sciences, Biochemistry, Molecular Biology +14

Studies on fluorinated pyrimidines. III. The metabolism of 5-fluorouracil-2-C14 and 5-fluoroorotic-2-C14 acid in vivo.

Betty Jo Montag, Charles Heidelberger · PubMed · 1958 · 250 citations

Medicine, Oncology, Pharmacology +14