PRONLONGED HYPOTHERMIC MACHINE PERFUSION PRESERVES HEPATOCELLULAR FUNCTION BUT POTENTIATES ENDOTHELIAL CELL DYSFUNCTION IN RAT LIVERS

Abstract

These results suggest that 24-hour hypothermic HMP may help preservation of hepatocyte function, but endothelial cell dysfunction during the cold preservation may play a key role in hepatocyte dysfunction and parenchymal cell death upon reperfusion.