Patterns of DNA‐Labeled and scFv‐Antibody‐Carrying Lipid Vesicles Directed by Material‐Specific Immobilization of DNA and Supported Lipid Bilayer Formation on an Au/SiO₂ Template

Abstract

Spots before the eyes: A material-specific surface modification protocol was developed to allow surface-directed immobilization of DNA-labeled lipid vesicles. The potential of similarly immobilized vesicles to act as carriers for water-soluble or transmembrane proteins in, for example, protein-chip applications was demonstrated. The picture shows how fluorescent vesicles labeled with different DNA strands have been directed to one of two complementary-DNA-modified Au spots surrounded by an inert supported lipid bilayer on SiO2.