Overcoming chemoresistance of non-small cell lung carcinoma through restoration of an AIF-dependent apoptotic pathway

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

Naoufal Zamzami, Philippe Marchetti, Maria Castedo et al. · The Journal of Experimental Medicine · 1995 · 1.6K citations · Full text

Apoptosis, Cell Death, Molecular Biology +17

Two Distinct Pathways Leading to Nuclear Apoptosis

Santos A. Susín, Éric Daugas, L Ravagnan et al. · The Journal of Experimental Medicine · 2000 · 732 citations · Full text

Programmed cell death and extrathymic reduction of Vβ8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B

Yojiro Kawabe, Atsuo Ochi · Nature · 1991 · 669 citations

Microbial Toxin, Microbial Pathogens, Mice Tolerant +15

AIF deficiency compromises oxidative phosphorylation

Nicola Vahsen, Céline Candé, Jean-Jacques Brière et al. · The EMBO Journal · 2004 · 618 citations · Full text

Inflammation, Reductive Stress, Biochemistry +5

Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide.

Liling Yang, Tetsuo Mashima, Shigeo Sato et al. · PubMed · 2003 · 238 citations

Therapeutic Effect, Apoptosis Protein, Medicine +15