Chemical Communications · 2007 · 69 citations · 16 references
Conformational ControlMedicinal ChemistryBiochemistryFunctional SelectivityNatural SciencesDrug DiscoveryMedicineG Protein-coupled ReceptorReceptor (Biochemistry)Conformational StudySynthetic Hcl ReceptorCentral Isophthalamide CoreMembrane Transport FluxNon-peptide LigandChemical BiologyPharmacologyBiomolecular Engineering
Replacement of the central isophthalamide core in a synthetic HCl receptor, with a 2,6-dicarboxamidopyridine, leads to a more preorganised molecular structure that exhibits higher chloride affinity and membrane transport flux.
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