Redox activation of Ref-1 potentiates cell survival following myocardial ischemia reperfusion injury

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh et al. · Genes & Development · 1999 · 3.6K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region.

Paolo Moi, Isadora Asunis, Antonio Cao et al. · Proceedings of the National Academy of Sciences · 1994 · 1.6K citations

Life Sciences, Genetics, Molecular Biology +17

Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages

Tetsuro Ishii, Ken Itoh, Satoru Takahashi et al. · Journal of Biological Chemistry · 2000 · 1.5K citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Identification and characterization of Ref‐1, a nuclear protein that facilitates AP‐1 DNA‐binding activity.

Steven Xanthoudakis, Tom Curran · The EMBO Journal · 1992 · 717 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +5

Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2

H.-C. Huang, Truyen Nguyen, Cecil B. Pickett · Proceedings of the National Academy of Sciences · 2000 · 539 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17