Isomeric Furanosesquiterpenes from the Portuguese Marine Sponge <i>Fasciospongia</i> sp.

Abstract

This paper reports the chemical study of a sample of Fasciospongia sp. collected along the Atlantic Portuguese coast. Three new isomeric furanosesquiterpenes, isomicrocionin-3 (1), (−)-microcionin-1 (2), and (−)-isomicrocionin-1 (3), were isolated along with the known (−)-ent-pallescensin A (4) and (−)-pallescensin-1 (5) from the ethyl acetate-soluble portion of the methanolic extract. The structures of the new compounds were elucidated by extensive spectroscopic studies. (−)-Microcionin-1 (2) tested positive against several Gram-negative bacteria.