Disease‐Modifying Effects of<scp>RHC</scp>80267 and<scp>JZL</scp>184 in a Pilocarpine Mouse Model of Temporal Lobe Epilepsy

Abstract

These findings suggest that RHC80267 treatment after the onset of SE could result in an amelioration of the effects found during the chronic epileptic period and yield an overall decrease in epileptic symptoms and comorbid conditions. Thus, alterations to endocannabinoid signaling may serve as a potential mechanism to prevent epileptogenesis and manipulation of this signaling pathway as a possible drug target.