Concepedia

Evidence for an enzymatic defect in the 4‐hydroxylation of debrisoquine by human liver.

DS Davies, GC Kahn, Sandra Murray, MJ Brodie

British Journal of Clinical Pharmacology · 1981 · 93 citations · 8 references

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References

8

POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN

A. Mahgoub, L. G. Dring, Jeffrey R. Idle et al. · The Lancet · 1977 · 1.2K citations

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Monooxygenase activity of human liver in microsomal fractions of needle biopsy specimens.

MJ Brodie, GC Kahn, DR Fletcher et al. · British Journal of Clinical Pharmacology · 1980 · 153 citations · Full text

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Polymorphism of carbon oxidation of drugs and clinical implications.

T.P. Sloan, A. Mahgoub, Richard Lancaster et al. · BMJ · 1978 · 117 citations · Full text

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Pharmacogenetic covariation of defective N-oxidation of sparteine and 4-hydroxylation of debrisoquine

Leif Bertilsson, H. J. Dengler, Michel Eichelbaum et al. · European Journal of Clinical Pharmacology · 1980 · 81 citations

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Deficient metabolism of debrisoquine and sparteine

T. Inaba, S V Otton, W. Kalow · Clinical Pharmacology & Therapeutics · 1980 · 64 citations

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