A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

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Protein kinase C inhibition by plant flavonoids

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Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells.

Eric J. Bernhard, Stephen B. Gruber, Ruth J. Muschel · Proceedings of the National Academy of Sciences · 1994 · 391 citations · Full text

Medicine, Cell Biology, Molecular Biology +15

Genistein exerts multiple suppressive effects on human breast carcinoma cells.

Zhi Ming Shao, Jiong Wu, Zhen Shen et al. · PubMed · 1998 · 300 citations

Medicine, Oncology, Pharmacology +15

Kinase Pathways in Chemoattractant-Induced Degranulation of Neutrophils: The Role of p38 Mitogen-Activated Protein Kinase Activated by Src Family Kinases

Attila Mócsai, Zoltán Jakus, Tibor Vántus et al. · The Journal of Immunology · 2000 · 290 citations · Full text

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