Infectivity of Fuso-Spirochetal Exudates for Guinea Pigs, Hamsters, Mice and Chick Embryos By Several Routes of Inoculation

Abstract

PREVIOUS investigators have reported the production of characteristic experimental lesions by inoculation of exudates from Vincent's and other fusospirochetal diseases in healthy animals of several species, including rabbits,'guinea pigs,5-8 mice, 5 9 hedgehogs,'0 monkeys, and a chimpanzee.'2 Hamsters and chick embryos do not seem to have been tested, and no previous attempt is known to have been made to determine the infectivity of these exudates by titration. The present investigation, part of a more extensive study of the bacteriology of fusospirochetal infections, includes roughly quantitative data on infectivity along with the results of efforts to determine which of the animals species tested is most satisfactory for titration and for maintenance of the infection by passage.