Physical dependence Induced In DBA/2J mice by benzodiazeplne receptor full agonists, but not by the partial agonist Ro 16-6028

Use of the specific benzodiazepine antagonist, Ro 15-1788, in studies of physiological dependence on benzodiazepines

R. Cumin, E. P. Bonetti, R. Scherschlicht et al. · Cellular and Molecular Life Sciences · 1982 · 95 citations

Medicine, Pharmacology, Pharmacotherapy +7

Chronic benzodiazepine administration. II. Discontinuation syndrome is associated with upregulation of gamma-aminobutyric acidA receptor complex binding and function.

Lawrence G. Miller, D J Greenblatt, Raynald Roy et al. · Journal of Pharmacology and Experimental Therapeutics · 1988 · 89 citations

Medicine, Neuroscience, Pharmacology +16

Ro 16-6028: A Novel Anxiolytic Acting as a Partial Agonist at the Benzodiazepine Receptor

L. Pieri, E. Bonetti, R. Schaffner et al. · Pharmacopsychiatry · 1988 · 89 citations

Medicine, Pharmacology, Pharmacotherapy +13

Experimental induction of benzodiazepine tolerance and physical dependence.

G.P. Ryan, N R Boisse · Journal of Pharmacology and Experimental Therapeutics · 1983 · 88 citations

Medicine, Pharmacology, Pharmacotherapy +16

The effect of a benzodiazepine antagonist, R015-1788, in diazepam dependent rats

Laura F. McNicholas, William R. Martin · Life Sciences · 1982 · 65 citations

Medicine, Neuroscience, Pharmacology +7