MicroRNA-21 Regulates hTERT via PTEN in Hypertrophic Scar Fibroblasts

Abstract

These data indicate that miR-21 regulates hTERT expression via the PTEN/PI3K/AKT signaling pathway by directly targeting PTEN, therefore controlling hypertrophic scar fibroblast cell growth. MiR-21 may be a potential novel molecular target for the treatment of hypertrophic scarring.