INDUCTION OF TRANSPLANTATION TOLERANCE WITH A SHORT COURSE OF TACROLIMUS(FK506)

Abstract

To our knowledge, this study represents the first demonstration of the induction of transplant tolerance across a two-haplotype full MHC barrier with a short course of immunosuppression in a large animal model. These studies may also have clinical applicability, because the time course required to induce tolerance was sufficiently short that the high drug levels required might be expected to be tolerated clinically with only transient toxicity.