The role of cGMP hydrolysing phosphodiesterases 1 and 5 in cerebral artery dilatation

Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats.

Michael J. Mulvany, W Halpern · Circulation Research · 1977 · 2.1K citations

Life Sciences, Cardiology, Physiology +12

Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle

Victoria M. Bolotina, Soheil Najibi, James Palacino et al. · Nature · 1994 · 1.7K citations

Natural Sciences, Biophysics, Physiology +12

Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.

John Garthwaite, Eric Southam, Caroline L. Boulton et al. · Molecular Pharmacology · 1995 · 1.1K citations

Life Sciences, Neurobiology, Neuroscience +15

Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction.

Mitra Boolell, Allen Mj, Ballard Sa et al. · PubMed · 1996 · 1.1K citations

Medicine, Pharmacology, Pharmacotherapy +10

Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro

Robert M. Wallis, Jackie D. Corbin, Sharron H. Francis et al. · The American Journal of Cardiology · 1999 · 510 citations

Medicine, Biochemistry, Pharmacology +17