Lactobacilli Producing Bispecific Llama-Derived Anti-Rotavirus Proteins <i>in vivo</i> for Rotavirus-Induced Diarrhea

Abstract

Expression of bispecific antibodies in lactobacilli resulted in slight improvement of their efficacy. Furthermore, increasing the specificity would theoretically reduce the rate of appearance of viral escape mutants and would have a broader capacity to be effective against a range of viral serotypes.