Inducible Nitric Oxide Synthase Isoform Is a Key Mediator of Leukostasis and Blood-Retinal Barrier Breakdown in Diabetic Retinopathy - Concepedia

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Inducible Nitric Oxide Synthase Isoform Is a Key Mediator of Leukostasis and Blood-Retinal Barrier Breakdown in Diabetic Retinopathy

243

Citations

42

References

2007

Year

Ermelindo C. Leal, Ayyakkannu Manivannan, Ken‐ichi Hosoya, Tetsuya Terasaki, José Cunha‐Vaz, Anto ́nio Francisco Ambro ́sio, John V. Forrester

Investigative Ophthalmology & Visual Science

Abstract

These results indicate that the iNOS isoform plays a predominant role in leukostasis and BRB breakdown. The mechanism involves ICAM-1 upregulation and tight junction protein downregulation.

References

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