Concepedia

PtII Binding to N1 of Cytosine: Strengthening the Watson-Crick Pair with Guanine and yet Confining Its pH Existence Range

W. Brüning, Roland K. O. Sigel, E. Freisinger, Bernhard Lippert

Angewandte Chemie International Edition · 2001 · 36 citations · 21 references

DOI

Concepts

Abstract

Stronger than the natural Watson–Crick base pairing is the association between N1-platinated cytosine and neutral, unplatinated guanine in DMSO. Nevertheless, in aqueous solution the Pt-containing associate I (M=Pt) is stable in a narrower pH range.

References

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The Effect of Metal Binding to the N7 Site of Purine Nucleotides on Their Structure, Energy, and Involvement in Base Pairing

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