Calcium channel block by (-)devapamil is affected by the sequence environment and composition of the phenylalkylamine receptor site

DNA sequencing with chain-terminating inhibitors

Frederick Sanger, S. Nicklen, Alan Coulson · Proceedings of the National Academy of Sciences · 1977 · 69.3K citations · Full text

Life Sciences, Microbiology, Molecular Biology +10

Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension

Robert M. Horton, Henry D. Hunt, Steffan N. Ho et al. · Gene · 1989 · 3.1K citations

Life Sciences, Genetics, Molecular Biology +10

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

Bertil Hille · The Journal of General Physiology · 1977 · 1.8K citations · Full text

Medicine, Pharmacology, Anesthesia +16

Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel

Atsushi Mikami, Keiji Imoto, Tsutomu Tanabe et al. · Nature · 1989 · 921 citations

Natural Sciences, Pharmacology, Physiology +16

Exocytotic Ca2+ channels in mammalian central neurons

Kathleen Dunlap, Jennifer I. Luebke, Timothy J. Turner · Trends in Neurosciences · 1995 · 917 citations

Life Sciences, Neurobiology, Neuroscience +14