Increased gene expression and inflammatory cell infiltration caused by electroporation are both important for improving the efficacy of DNA vaccines

Increased DNA Vaccine Delivery and Immunogenicity by Electroporation In Vivo

Georg Widera, Melissa A. Austin, Dietmar Rabussay et al. · The Journal of Immunology · 2000 · 601 citations · Full text

Pharmacy, Biotechnology, Immunology +17

Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs

Arthur Μ. Krieg, Tong Wu, Risini D. Weeratna et al. · Proceedings of the National Academy of Sciences · 1998 · 401 citations

Life Sciences, Immunology, Molecular Biology +14

A Rev-Independent Human Immunodeficiency Virus Type 1 (HIV-1)-Based Vector That Exploits a Codon-Optimized HIV-1 <i>gag-pol</i> Gene

Ekaterini Kotsopoulou, V. Narry Kim, Alan J. Kingsman et al. · Journal of Virology · 2000 · 229 citations

Life Sciences, Molecular Biology, Molecular Genetics +17

Electroporation improves the efficacy of DNA vaccines in large animals

Shawn Babiuk · Vaccine · 2002 · 185 citations

Veterinary Medicine, Biotechnology, Immunology +14

DNA immunization circumvents deficient induction of T helper type 1 and cytotoxic T lymphocyte responses in neonates and during early life

Xavier Martínez, Christian Brandt, Fatiha Saddallah et al. · Proceedings of the National Academy of Sciences · 1997 · 163 citations

Life Sciences, Immunology, Infectious Diseases +17