Asialo GM₁as a Cell-Surface Marker Detected in Acute Lymphoblastic Leukemia

Abstract

The heterologous antiserum raised against brain-associated T-cell antigen may react against some immature cells distinct from mature T cells.1 2 3 4 5 6 7 8 Studies in our laboratory have identified the constituent antibody in this antiserum as an antibody against the glycolipid asialo GM1, which exists on non-T, non-B populations such as the natural killer cells of mice.9 We have tried to determine whether the antiserum raised against purified asialo GM1 can distinguish neoplastic lymphoid cells from normal lymphocytes.Peripheral blood lymphocytes from 60 patients with lymphoid neoplasia and hematologic disorders were analyzed for the presence of glycolipid asialo GM1 as . . .