Concepedia

Synthesis and biological evaluation of 4-fluoroproline and 4-fluoropyrrolidine-2-acetic acid derivatives as new GABA uptake inhibitors

Weiping Zhuang, Xueqing Zhao, Gang Zhao, Lihe Guo, Yun-Yang Lian, Jingming Zhou, Dongsheng Fang

Bioorganic & Medicinal Chemistry · 2009 · 15 citations · 26 references

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Concepts

References

26

Fluorine substituent effects (on bioactivity)

Bruce E. Smart · Journal of Fluorine Chemistry · 2001 · 1.5K citations

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Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments

Kenneth L. Kirk · Organic Process Research & Development · 2008 · 1.1K citations

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Huntington's Disease

Jean Stipe, Dorothy A. White, Eleanor Van Arsdale · AJN American Journal of Nursing · 1979 · 604 citations

, , +17

100 Years of the Wolff Rearrangement

Wolfgang Kirmse · European Journal of Organic Chemistry · 2002 · 526 citations

, , +9

The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (Tiagabine) as an anticonvulsant drug candidate

Knud Erik Andersen, Frederik C. Groenwald, A. JOERGENSEN et al. · Journal of Medicinal Chemistry · 1993 · 151 citations

, , +10