Circadian Clock-Controlled Intestinal Expression of the Multidrug-Resistance Gene mdr1a in Mice

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Alfred H. Schinkel, Jasper Smit, Olaf van Tellingen et al. · Cell · 1994 · 2.3K citations

Medicine, Pharmacokinetics, Pharmacology +14

The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator

Nicolas Preitner, Francesca Damiola, Luis Lopez‐Molina et al. · Cell · 2002 · 2.2K citations · Full text

Life Sciences, Genetics, Molecular Biology +14

Role of the CLOCK Protein in the Mammalian Circadian Mechanism

Nicholas Gekakis, David Staknis, Hubert B. Nguyen et al. · Science · 1998 · 2K citations

Life Sciences, Genetics, Molecular Biology +16

Mutagenesis and Mapping of a Mouse Gene, <i>Clock</i> , Essential for Circadian Behavior

Martha Hotz Vitaterna, David P. King, Anne‐Marie Chang et al. · Science · 1994 · 1.6K citations

Life Sciences, Genetics, Molecular Genetics +17

mCRY1 and mCRY2 Are Essential Components of the Negative Limb of the Circadian Clock Feedback Loop

Kazuhiko Kume, Mark J. Zylka, Sriram Sathyanarayanan et al. · Cell · 1999 · 1.6K citations · Full text

Life Sciences, Molecular Biology, Physiology +16