Concepedia

Helicobacter pylori CagA targets gastric tumor suppressor RUNX3 for proteasome-mediated degradation

Ying Hung Tsang, Acacia Lamb, Judith Romero–Gallo, Bo Huang, Kosei Ito, Richard M. Peek, Yoshiaki Ito, L F Chen

Oncogene · 2010 · 102 citations · 22 references

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22

Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach.

Martin J. Blaser, Harry Kleanthous, Timothy L. Cover et al. · PubMed · 1995 · 1.6K citations

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Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer

Qing-Lin Li, Kosei Ito, Chohei Sakakura et al. · Cell · 2002 · 1K citations · Full text

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SHP-2 Tyrosine Phosphatase as an Intracellular Target of <i>Helicobacter pylori</i> CagA Protein

Hideaki Higashi, Ryouhei Tsutsumi, Syuichi Muto et al. · Science · 2002 · 1K citations

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Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection.

Julie Parsonnet, G D Friedman, Norman Orentreich∥ et al. · Gut · 1997 · 968 citations · Full text

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Transgenic expression of <i>Helicobacter pylori</i> CagA induces gastrointestinal and hematopoietic neoplasms in mouse

Naomi Ohnishi, Hitomi Yuasa, Shinya Tanaka et al. · Proceedings of the National Academy of Sciences · 2008 · 585 citations · Full text

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