Role of Inositol 1,4,5-Triphosphate and p38 Mitogen-Activated Protein Kinase in Reactive Oxygen Species Generation by Granulocytes in a Cyclic AMP-Dependent Manner: An Age-Related Phenomenon

Abstract

The present study may be important towards a better understanding of the high susceptibility to infections and age-related inflammatory and deregulation diseases. The alteration of cAMP/PKA and p38 MAPK signaling pathways enhances the inflammatory process.