Transport of small molecules through the blood-brain barrier: biology and methodology

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Alfred H. Schinkel, Jasper Smit, Olaf van Tellingen et al. · Cell · 1994 · 2.3K citations

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Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

Carlos Cordon‐Cardo, James P. O’Brien, D Casals et al. · Proceedings of the National Academy of Sciences · 1989 · 1.7K citations · Full text

Medicine, Oncology, Pharmacology +16

Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection

WH Oldendorf · American Journal of Physiology-Legacy Content · 1971 · 1.7K citations

Life Sciences, Neurobiology, Neuroscience +9

<b>The Permeability of Capillaries in Various Organs as Determined by Use of the ‘Indicator Diffusion’ Method</b>

Christian Crone · Acta Physiologica Scandinavica · 1963 · 1.2K citations

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Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

Victor A. Levin · Journal of Medicinal Chemistry · 1980 · 814 citations

Medicine, Pharmacology, Physiology +14