Drug-Sensitized Zebrafish Screen Identifies Multiple Genes, Including <i>GINS3</i> , as Regulators of Myocardial Repolarization

Abstract

This sensitized zebrafish screen identified 15 novel myocardial repolarization genes. Among these genes is GINS3, the human ortholog of which is a major locus in 2 concurrent human genome-wide association studies of QT interval. These results reveal a novel network of genes that regulate cardiac repolarization.