Autophagy · 2011 · 129 citations · 0 references
Life SciencesImmunologyMolecular BiologyAutophagyInflammationInnate ImmunityAutophagy In Stress ResponsesInflammatory Cell ResponsesInflammatory SignalingInnate Immune Signaling PathwaysMacrophage BiologyToll-like ReceptorsAcute Inflammatory ResponseAutophagic HomeostasisAutophagy-related Inflammatory SignalingInflammatory AutophagyInflammatory Stress ResponsesMacrophage Inflammatory ResponsesMacrophage Signaling PathwaysPhagocyte-autophagy Interactions
Toll-like receptor (TLR) signaling is an important part of the innate immune response. One of the downstream responses to TLR4 signaling upon lipopolysaccharide (LPS) stimulation is the induction of autophagy, which is a key response to multiple stressors. An additional adaptive signaling molecule that is involved in the response to stress is heme oxygenase-1 (HO-1). HO-1 signaling is essential to limit inflammation and restore homeostasis. We found that LPS induced autophagic signaling in macrophages via a TLR4, HO-1 dependent pathway in macrophages. These data add to the developing contribution of autophagic signaling as part of the inflammatory response.