DPP10 Modulates Kv4-mediated A-type Potassium Channels

Abstract

A new member of a family of proteins characterized by structural similarity to dipeptidyl peptidase (DPP) IV known as DPP10 was recently identified and linked to asthma susceptibility; however, the cellular functions of DPP10 are thus far unknown. DPP10 is highly homologous to subfamily member DPPX, which we previously reported as a modulator of Kv4-mediated A-type potassium channels (Nadal, M. S., Ozaita, A., Amarillo, Y., Vega-Saenz de Miera, E., Ma, Y., Mo, W., Y., Y., A., and the of DPP10 to the of channels DPP10 to to and and DPP10 to the A-type and the and of the the of A-type the we DPP10 to DPP10 was the of DPP10 proteins DPP10 to the of A-type the the structural of we of DPPX, and the of and to the of the of the and A new member of a family of proteins characterized by structural similarity to dipeptidyl peptidase (DPP) IV known as DPP10 was recently identified and linked to asthma susceptibility; however, the cellular functions of DPP10 are thus far unknown. DPP10 is highly homologous to subfamily member DPPX, which we previously reported as a modulator of Kv4-mediated A-type potassium channels (Nadal, M. S., Ozaita, A., Amarillo, Y., Vega-Saenz de Miera, E., Ma, Y., Mo, W., Y., Y., A., and the of DPP10 to the of channels DPP10 to to and and DPP10 to the A-type and the and of the the of A-type the we DPP10 to DPP10 was the of DPP10 proteins DPP10 to the of A-type the the structural of we of DPPX, and the of and to the of the of the and recently identified a new member of a family of proteins characterized by structural similarity to dipeptidyl peptidase (DPP) dipeptidyl dipeptidyl IV known as is a is a to the of the of and is as a the of functions cellular and of which are by the M. M. is the member of a of is the as as and functions to DPP10 was recently identified as a to a of the and to M. M. M. linked to a homologous to the of DPP10 M. M. DPP10 to and is by the of of cellular we to a to the of DPP10 is to known as DPPX, the of the the by and is DPP10 was to and DPP10 as peptidase is a of the of recently is the of Kv4-mediated A-type channels and the cellular and of channels Vega-Saenz de the DPP10 and and to the functions of we to Kv4-mediated A-type to the of DPP10 to proteins to the and to the of the of the the and DPP10 is by DPP10 is known to M. and DPP10 was to the of the and DPP10 as a subfamily to and a the of of DPP10 potassium of is the of DPP10 and asthma of and and the as by the DPPX, was and to the previously identified as Vega-Saenz de as we a of the and and and and was and to to and the we a a the of the the of potassium and to and to was and was to and and was as a was a of by was to the of and and the of of by of and DPP10 the and and and the and and the to and and and to the proteins the by of proteins the and by and as previously was by and of of as previously Vega-Saenz de was a as previously Vega-Saenz de to as previously Vega-Saenz de the the was to by and the the by and proteins by as previously Vega-Saenz de a of by and a to and as previously Vega-Saenz de and by as previously Vega-Saenz de the and DPP10 of to DPP10 was a and to a of and to a of DPP10 A DPP10 was and the and the was the by of the was as previously was as previously and the of a was of to the of to the of proteins are of potassium channels to of the proteins the Vega-Saenz de M. of reported to and to a potassium Vega-Saenz de DPP10 is to the of proteins to the DPPX, and was of the A of was was proteins to the reported previously Vega-Saenz de and a of to the DPPX, DPP10 of DPPX, DPP10 to the of the the of the and the of to the DPP10 and a was the was the of by was to of to a the and of the to of and DPPX, DPP10 and DPP10 by and to to the of and DPP10 are the of which and of the to the of DPPX, and are A-type DPP10 by the a of and to to by to of the of the of the DPP10 is to to DPPX, DPP10 and DPP10 and to is and and and and and DPP10 the to and the and of to of A-type by was the the and DPP10 a to and and the and and of and of the of channels is the of the of of the A-type a Vega-Saenz de is of the A-type the by proteins Vega-Saenz de Vega-Saenz de DPP10 to to was and DPP10 the of the by the of DPP10 we the of the Kv4-mediated A was to the of the the of and as reported previously Kv4-mediated and the Vega-Saenz de Vega-Saenz de DPP10 DPPX, we the was DPP10 and the and of the the of DPP10 is to the of the the of the is and DPP10 the of the the of the by to and DPP10 DPP10 and a of the and of by and is the of A-type and DPP10 to a to the by A is of the of the A-type by DPPX, and DPP10 and is the and DPP10 the of of of was to the of to A was reported Vega-Saenz de a the of channels DPP10 the of the was of which is of the of of A-type the the which and DPP10 the we a which the of to and the of are highly as as the of was highly the of and to and of the are the of the DPPX, the the of and was was by the of to and the of by are of A was the the and are the and the to are the highly the and the the the of the of the of which the of and and the and highly the and the of the of the Kv4-mediated and to of DPP10 and the and of channels a to the of DPP10 the the A-type Vega-Saenz de and DPP10 a subfamily of DPP10 the of channels to DPP10 DPP10 and subfamily the family the similarity and we and to the structural DPP10 and and to of of the of the and of DPPX, and and are and DPP10 are DPP10 similarity similarity DPP10 and the of the of DPPX, and of the of and DPP10 the of the of as a the of the of is of and the of DPP10 and DPPX, are of the of the and of the proteins a the of and DPP10 are is the of the to a is the of DPP10 and and is a of the of DPP10 and and and the of DPP10 and of highly a and of the are the of the is DPP10 and and are the the and DPP10 are the the of is and DPP10 are and the of structural similarity DPP10 and the and and of and DPP10 the of structural of and DPP10 to potassium we proteins by a of and and the and the of the proteins was and we and the of of the and the the and the was the and of and channels to the and of proteins which the of to the of and and of a the of the was and proteins to a of DPPX, and to the of are and Kv4-mediated by and to the of the and of the to to the was by and a to was by and to and the was the to the and of the of of was by to was the the of and DPP10 to the and of channels the of and the and of the the of the and and and a the of to the and are the and of as the the the the and of channels by and DPP10 are by and of and the and of are of the of the A-type by and a the of the by the to to to of as the which of the to of the to a by the to a the of the of of Kv4-mediated a and the of and the of of and DPP10 and the of a the the of to of and DPP10 and and to we the and DPP10 the of of the of and by the structural of the and DPPX, and the of the DPP10 is M. 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