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Unstable expression of transgene is associated with the methylation of CAG promoter in the offspring from the same litter of homozygous transgenic mice

Knockout MouseDevelopmental BiologyMedicineGeneticsDna MethylationCag PromoterEpigenetic ChangeGenetic EngineeringMolecular GeneticsSame LitterDna DemethylationGene ExpressionUnstable ExpressionEpigeneticsGene Transfer