Cholesterol Accumulation Is Associated with Lysosomal Dysfunction and Autophagic Stress in Npc1−/− Mouse Brain

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

The EMBO Journal · 2000 · 6.5K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +11

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Taichi Hara, Kenji Nakamura, Makoto Matsui et al. · Nature · 2006 · 3.8K citations

Life Sciences, Neurobiology, Neuroscience +12

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Masaaki Komatsu, Satoshi Waguri, Tomoki Chiba et al. · Nature · 2006 · 3.5K citations

Life Sciences, Neurobiology, Neuroscience +10

Inhibition of Macroautophagy Triggers Apoptosis

Patricia Boya, Rosa A. González‐Polo, Noëlia Casares et al. · Molecular and Cellular Biology · 2005 · 1.6K citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study

Ralph A. Nixon, Jerzy Węgiel, Asok Kumar et al. · Journal of Neuropathology & Experimental Neurology · 2005 · 1.6K citations · Full text

Life Sciences, Neuroscience, Pathology +14