Concepedia

Leptin Interferes with Adrenocorticotropin/3′,5′-Cyclic Adenosine Monophosphate (cAMP) Signaling, Possibly through a Janus Kinase 2-Phosphatidylinositol 3-Kinase/Akt-Phosphodiesterase 3-cAMP Pathway, to Down-Regulate Cholesterol Side-Chain Cleavage Cytochrome P450 Enzyme in Human Adrenocortical NCI-H295 Cell Line

Haoting Hsu, Yuan‐Ching Chang, Yi-Ning Chiu, Chien‐Liang Liu, King‐Jen Chang, Ing-Cherng Guo

The Journal of Clinical Endocrinology & Metabolism · 2006 · 38 citations · 34 references

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Abstract

Leptin interferes with ACTH/cAMP signaling, possibly through a cAMP-degrading mechanism involving activation of JAK2, phosphatidylinositol 3-kinase, and PDE3, to down-regulate P450scc expression and consequent adrenal steroidogenesis.

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